A CoNTeMpoRARy Review of expeRiMeNTAl STuDieS
نویسندگان
چکیده
vol. 6, No. 6, JuNe 2017 385 Article focus Distraction osteogenesis (Do) harnesses the bone regenerative potential of bone and avoids the complications of other treatments such as bone grafting. The major disadvantage of Do is the length of time required for bone consolidation. Mesenchymal stem cells (MSCs) have been used to promote bone formation in this phase, with some good results. This review focuses on the use of MSCs in promoting bone consolidation during Do. Studies differed in animal type (mice, rabbit, dog, sheep), bone type (femur, tibia, skull), Do protocols and cell transplantation methods. Most studies reported that the transplantation of MSCs enhanced bone consolidation or formation in Do. Many questions relating to the animal model, Do protocol and cell transplantation regime require further investigation. A consensus is required on this before further research is undertaken. Clinical trials are needed to test and confirm these findings once a consensus has been agreed on the protocols involving animal studies.
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